Optical Phantoms: Diffuse and Sub-diffuse Imaging and Spectroscopy Validation

Optical Phantoms: Diffuse and Sub-diffuse Imaging and Spectroscopy Validation
Author(s):    Gage J. Greening; Haley M. James; Timothy J. Muldoon
Published:   2015
DOI:             10.1117/3.2226012
eISBN: 9781628416770
Description:

This Spotlight describes the use of optical phantoms as validation tools for probe-based imaging and spectroscopy platforms. Composition of optical phantoms, including scattering and absorbing agents, is discussed in the context of their specific application. Next, requirements for designing optical phantoms for validation of small endoscopic instrumentation is presented including a discussion on the diffuse and sub-diffuse scattering regimes and how this relates to common types of epithelial tissue. This book concludes with a tutorial section for constructing solid phantoms to simulate thin epithelial tissue structure and liquid phantoms to extract tissue optical properties using probe-based reflectance spectroscopy techniques. For these applications, solid phantoms are made using poly(dimethylsiloxane) and liquid phantoms are made using deionized water as the substrate material. The scope of the chapter is limited to optical phantom design and application and is not intended to describe the physics, instrumentation, or mathematical or computational modeling of the various techniques mentioned in detail.

Please Wait... Processing your request... Please Wait.

Optical phantoms are a widely used tool to validate optical instrumentation. In essence, phantoms are “false tissues” made of various materials and can be liquid, solid, or gelatinous. Generally, phantoms are made to either simulate a tissue’s optical, mechanical, chemical, or physical properties, or a combination of these. These structures are typically comprised of a base substrate material, which can be doped with certain additives that give the material specific optical, mechanical, or chemical properties. Additionally, depending on the substrate material used and desired geometry, optical phantoms can be molded into a variety of shapes and sizes for different applications.

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.

Your library does not currently subscribe to eBooks on the SPIE Digital Library. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.