Light Scattering Spectroscopy of Epithelial Tissues: Principles and Applications

Perelman, Lev T.; Backman, Vadim

doi:10.1117/3.2219608.ch2

Book: Handbook of Optical Biomedical Diagnostics, Second Edition, Volume 2: Methods

Editor(s): Valery V. Tuchin

Author(s): Lev Perelman, Vadim Backman

Published: 2016

https://doi.org/10.1117/3.2219608.ch2

Abstract

Over the past decades, substantial progress has been made in medical diagnostic technologies that target anatomic changes at the organ level. Techniques such as magnetic resonance imaging (MRI) and spectroscopy (MRS), x-ray computed tomography (X-ray CT), and ultrasound make it possible to “see through the human body.” At the same time, there is clearly a need for the development of diagnostic techniques that use our current knowledge of the cellular and subcellular bases of disease. The diagnostic techniques applicable in situ (inside the human body) that can provide structural and functional information about the tissue at the cellular and subcellular levels, the kind of information that is currently obtainable using only in vitro methods requiring tissue removal, will have great implications for the detection and prevention of diseases as well as targeted therapy.