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The challenge for optical biosensors aimed at near patient testing is to achieve high performance at low cost, which includes the source and the readout instrumentation; this naturally requires trading off the various parameters of the system. We describe our sensor modality utilizing guided mode resonances, put it into context and discuss how this trade-off can be optimized for designing a viable device. We show how the technology can detect multiple markers for infection, combine the sensing and the spectrometer function in a single chip and achieve a limit of detection as low as 1pg/ml for common markers of infection. This performance is equivalent or better than laboratory-based techniques yet the sensor and instrumentation can be made entirely from low-cost components.
Thomas F. Krauss
"High-performance low-cost biosensors: opportunities and limitations", Proc. SPIE PC12196, Active Photonic Platforms 2022, PC121961G (3 October 2022); https://doi.org/10.1117/12.2633509
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Thomas F. Krauss, "High-performance low-cost biosensors: opportunities and limitations," Proc. SPIE PC12196, Active Photonic Platforms 2022, PC121961G (3 October 2022); https://doi.org/10.1117/12.2633509