PRESTO, a novel non-invasive tool for detection and assessment of skin lesions based on protoporphyrin IX (PPIX) fluorescence and the microvascular dynamics of pressing on the tissue

Arthur F. Pétusseau; Petr Bruza; Brian Pogue

doi:10.1117/12.3004512

13 March 2024 PRESTO, a novel non-invasive tool for detection and assessment of skin lesions based on protoporphyrin IX (PPIX) fluorescence and the microvascular dynamics of pressing on the tissue

Arthur F. Pétusseau, Petr Bruza, Brian Pogue

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Proceedings Volume PC12816, Photonics in Dermatology and Plastic Surgery 2024; PC1281606 (2024) https://doi.org/10.1117/12.3004512
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Introducing PRESS (Pressure Enhanced Sensing Surgery) – a groundbreaking method to image hypoxia in skin lesions. Chaotic, weak blood vessels in tumors cause microregional chronic and cycling hypoxia, and low-pressure blood flow. PRESS takes advantage of the FDA-approved drug aminolaevulinic acid, to imply the synthesis of Protoporphyrin IX (PpIX) in tissue. PpIX's delayed fluorescence (DF) serves as a unique indicator of local oxygen levels, particularly in mitochondria, making it ideal for tissue oxygen measurement. Enhanced signal resolution is achieved through palpation, capturing both chronic and pressure-induced transient hypoxia. In dermatology, PRESS shows great promise for assessing tissue types and malignancy margins, especially with the widespread use of ALA for skin lesion treatments. Preliminary results from the first clinical trial highlight its potential in dermatological applications.

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Arthur F. Pétusseau, Petr Bruza, and Brian Pogue "PRESTO, a novel non-invasive tool for detection and assessment of skin lesions based on protoporphyrin IX (PPIX) fluorescence and the microvascular dynamics of pressing on the tissue", Proc. SPIE PC12816, Photonics in Dermatology and Plastic Surgery 2024, PC1281606 (13 March 2024); https://doi.org/10.1117/12.3004512

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KEYWORDS

Tissues

Fluorescence

Hypoxia

Skin

Dermatology

Reflection

Resolution enhancement technologies

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