Tatiana Soldati,1 Sofi M. Vassileva,2 Margherita Vaselli,1 Kirsten A. Kalverda,2 Pieta C. Wijsman,2 Jouke T. Annema,2 Peter I. Bonta,2 Johannes F. de Boer1
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Currently, no diagnostic method exists to visualize and measure the airway smooth muscle (ASM) in vivo. Endoscopic Polarization Sensitive Optical Coherence Tomography (PS-OCT) has the potential to detect and quantify the ASM, by assessing tissue birefringence. We performed in vivo PS-OCT in patients (n=17) with airway diseases (asthma and interstitial lung disease) and one healthy volunteer. PS-OCT images were acquired with an in-house built distal scanning catheter (1.35mm), which allowed circumferential scan of the airways at 52 fps B-scan rate. We demonstrated PS-OCT to be a minimally invasive technique to assess ASM thickness in diseased airways relative to healthy subjects.
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Tatiana Soldati, Sofi M. Vassileva, Margherita Vaselli, Kirsten A. Kalverda, Pieta C. Wijsman, Jouke T. Annema, Peter I. Bonta, Johannes F. de Boer, "In vivo endoscopic polarization sensitive OCT for the quantification of airway smooth muscle in airway disease and healthy volunteers," Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128301Q (13 March 2024); https://doi.org/10.1117/12.3005436