Investigation of optical coherence tomography and elastography for visualization of human prostate microarchitecture

Marta K. Skrok; Tamborski Szymon; Matt S Hepburn; Qi Fang; Mateusz Maniewski M.D.; Marek Zdrenka M.D.; Maciej Szkulmowski; Adam Kowalewski; Brendan Kennedy; Łukasz Szylberg

doi:10.1117/12.3023391

13 March 2024 Investigation of optical coherence tomography and elastography for visualization of human prostate microarchitecture

Marta K. Skrok, Tamborski Szymon, Matt S Hepburn, Qi Fang, Mateusz Maniewski M.D., Marek Zdrenka M.D., Maciej Szkulmowski, Adam Kowalewski, Brendan Kennedy, Łukasz Szylberg

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Proceedings Volume PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII; PC128310H (2024) https://doi.org/10.1117/12.3023391
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Prostate cancer represents 7% of all new cancer cases worldwide. There remain important challenges in the diagnosis and treatment of prostate cancers, particularly to increase biopsy accuracy and to enable nerve-sparing surgery. Here, we explore the capability of wide-field optical coherence tomography (OCT) and optical coherence elastography (OCE), spanning up to 45x45 mm in the lateral field of view and to depths of 1 mm, to accurately identify prostate microarchitecture. In this study, we present novel methodology to systematically validate OCT and OCE images through co-registration with standard histology on 15 human prostate specimens and demonstrate the potential for intraoperative use.

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Marta K. Skrok, Tamborski Szymon, Matt S Hepburn, Qi Fang, Mateusz Maniewski M.D., Marek Zdrenka M.D., Maciej Szkulmowski, Adam Kowalewski, Brendan Kennedy, and Łukasz Szylberg "Investigation of optical coherence tomography and elastography for visualization of human prostate microarchitecture", Proc. SPIE PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, PC128310H (13 March 2024); https://doi.org/10.1117/12.3023391

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