3D printing of tissue-simulating phantoms for calibration of biomedical optical devices

Zuhua Zhao; Ximing Zhou; Shuwei Shen; Guangli Liu; Li Yuan; Yuquan Meng; Xiang Lv; Pengfei Shao; Erbao Dong; Ronald X. Xu

doi:10.1117/12.2246273

31 October 2016 3D printing of tissue-simulating phantoms for calibration of biomedical optical devices

Zuhua Zhao, Ximing Zhou, Shuwei Shen, Guangli Liu, Li Yuan, Yuquan Meng, Xiang Lv, Pengfei Shao, Erbao Dong, Ronald X. Xu

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100240N (2016) https://doi.org/10.1117/12.2246273
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

Clinical utility of many biomedical optical devices is limited by the lack of effective and traceable calibration methods. Optical phantoms that simulate biological tissues used for optical device calibration have been explored. However, these phantoms can hardly simulate both structural and optical properties of multi-layered biological tissue. To address this limitation, we develop a 3D printing production line that integrates spin coating, light-cured 3D printing and Fused Deposition Modeling (FDM) for freeform fabrication of optical phantoms with mechanical and optical heterogeneities. With the gel wax Polydimethylsiloxane (PDMS), and colorless light-curable ink as matrix materials, titanium dioxide (TiO₂) powder as the scattering ingredient, graphite powder and black carbon as the absorption ingredient, a multilayer phantom with high-precision is fabricated. The absorption and scattering coefficients of each layer are measured by a double integrating sphere system. The results demonstrate that the system has the potential to fabricate reliable tissue-simulating phantoms to calibrate optical imaging devices.

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Zuhua Zhao, Ximing Zhou, Shuwei Shen, Guangli Liu, Li Yuan, Yuquan Meng, Xiang Lv, Pengfei Shao, Erbao Dong, and Ronald X. Xu "3D printing of tissue-simulating phantoms for calibration of biomedical optical devices", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100240N (31 October 2016); https://doi.org/10.1117/12.2246273

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