Non-invasive optical detection of HBV based on serum surface-enhanced Raman spectroscopy

Zuci Zheng; Qiwen Wang; Cuncheng Weng; Xueliang Lin; Yao Lin; Shangyuan Feng

doi:10.1117/12.2247671

31 October 2016 Non-invasive optical detection of HBV based on serum surface-enhanced Raman spectroscopy

Zuci Zheng, Qiwen Wang, Cuncheng Weng, Xueliang Lin, Yao Lin, Shangyuan Feng

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100244S (2016) https://doi.org/10.1117/12.2247671
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

An optical method of surface-enhanced Raman spectroscopy (SERS) was developed for non-invasive detection of hepatitis B surface virus (HBV). Hepatitis B virus surface antigen (HBsAg) is an established serological marker that is routinely used for the diagnosis of acute or chronic hepatitis B virus(HBV) infection. Utilizing SERS to analyze blood serum for detecting HBV has not been reported in previous literature. SERS measurements were performed on two groups of serum samples: one group for 50 HBV patients and the other group for 50 healthy volunteers. Blood serum samples are collected from healthy control subjects and patients diagnosed with HBV. Furthermore, principal components analysis (PCA) combined with linear discriminant analysis (LDA) were employed to differentiate HBV patients from healthy volunteer and achieved sensitivity of 80.0% and specificity of 74.0%. This exploratory work demonstrates that SERS serum analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of HBV.

Citation Download Citation

Zuci Zheng, Qiwen Wang, Cuncheng Weng, Xueliang Lin, Yao Lin, and Shangyuan Feng "Non-invasive optical detection of HBV based on serum surface-enhanced Raman spectroscopy", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100244S (31 October 2016); https://doi.org/10.1117/12.2247671

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