Hypericin-mediated selective photomodification of connective tissues

V. Hovhannisyan; A. Hovhannisyan; V. Ghukasyan; H. W. Guo; Hung-Ming Lin; S. J. Chen; Yang-Fang Chen; Chen-Yuan Dong

doi:10.1117/12.2255028

13 February 2017 Hypericin-mediated selective photomodification of connective tissues

V. Hovhannisyan, A. Hovhannisyan, V. Ghukasyan, H. W. Guo, Hung-Ming Lin, S. J. Chen, Yang-Fang Chen, Chen-Yuan Dong

Proceedings Volume 10037, Photonics in Dermatology and Plastic Surgery; 100370O (2017) https://doi.org/10.1117/12.2255028
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Hypericin (Hyp) has received attention due to its high phototoxicity against viruses and anti-tumor photoactivity. Using two-photon imaging, we demonstrated that Hyp induced photosensitized modification of collagen fibers in native tissues. Dynamics of photo-processes was monitored by time-lapse multiphoton imaging. We showed that Hyp–mediated processes in collagen tissues may be used for the selective modification of collagen fibers.

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V. Hovhannisyan, A. Hovhannisyan, V. Ghukasyan, H. W. Guo, Hung-Ming Lin, S. J. Chen, Yang-Fang Chen, and Chen-Yuan Dong "Hypericin-mediated selective photomodification of connective tissues", Proc. SPIE 10037, Photonics in Dermatology and Plastic Surgery, 100370O (13 February 2017); https://doi.org/10.1117/12.2255028

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