A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT

Timothy C. Zhu; Michele M. Kim; Yi-Hong Ong; Rozhin Penjweini; Andreea Dimofte; Jarod C. Finlay; Carmen Rodriguez; Keith A. Cengel

doi:10.1117/12.2253027

21 February 2017 A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT

Timothy C. Zhu, Michele M. Kim, Yi-Hong Ong, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Carmen Rodriguez, Keith A. Cengel

Author Affiliations +

Proceedings Volume 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI; 1004709 (2017) https://doi.org/10.1117/12.2253027
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. A dualcorrection algorithm is used to improve the agreement between calculations and in-situ measurements. A comprehensive analysis of the distribution of light fluence during PDT is presented in both phantom conditions and in clinical cases.

Conference Presentation

Citation Download Citation

Timothy C. Zhu, Michele M. Kim, Yi-Hong Ong, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Carmen Rodriguez, and Keith A. Cengel "A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT", Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 1004709 (21 February 2017); https://doi.org/10.1117/12.2253027

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available