Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

Konstantin S. Yashin; Elena B. Kiseleva; Ekaterina V. Gubarkova; Lev A. Matveev; Maria M. Karabut; Vadim V. Elagin; Marina A. Sirotkina; Igor A. Medyanik; L. Ya. Kravets; Natalia D. Gladkova

doi:10.1117/12.2252286

8 February 2017 Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

Konstantin S. Yashin, Elena B. Kiseleva, Ekaterina V. Gubarkova, Lev A. Matveev, Maria M. Karabut, Vadim V. Elagin, Marina A. Sirotkina, Igor A. Medyanik, L. Ya. Kravets, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 10050, Clinical and Translational Neurophotonics; 100500Z (2017) https://doi.org/10.1117/12.2252286
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In the case of infiltrative brain tumors the surgeon faces difficulties in determining their boundaries to achieve total resection. The aim of the investigation was to evaluate the performance of multimodal OCT (MM OCT) for differential diagnostics of normal brain tissue and glioma using an experimental model of glioblastoma. The spectral domain OCT device that was used for the study provides simultaneously two modes: cross-polarization and microangiographic OCT. The comparative analysis of the both OCT modalities images from tumorous and normal brain tissue areas concurrently with histologic correlation shows certain difference between when accordingly to morphological and microvascular tissue features.

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Konstantin S. Yashin, Elena B. Kiseleva, Ekaterina V. Gubarkova, Lev A. Matveev, Maria M. Karabut, Vadim V. Elagin, Marina A. Sirotkina, Igor A. Medyanik, L. Ya. Kravets, and Natalia D. Gladkova "Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma", Proc. SPIE 10050, Clinical and Translational Neurophotonics, 100500Z (8 February 2017); https://doi.org/10.1117/12.2252286

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