Multispectral fluorescence diffuse optical tomography

Pei-An Lo; Jaedu Cho; Farouk Nouizi; Huihua Kenny Chiang; Gultekin Gulsen

doi:10.1117/12.2251363

14 March 2017 Multispectral fluorescence diffuse optical tomography

Pei-An Lo, Jaedu Cho, Farouk Nouizi, Huihua Kenny Chiang, Gultekin Gulsen

Proceedings Volume 10056, Design and Quality for Biomedical Technologies X; 100560Z (2017) https://doi.org/10.1117/12.2251363
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Fluorescence diffuse optical tomography (FDOT) has been widely used for in vivo small animal studies and the illposed problem in reconstruction can be eased by utilizing structural a priori obtained from an anatomic imaging modality. In this study, a multispectral fluorescence tomography (FT) is used, which has shown the ability to detect subtle shifts in the ICG absorption spectrum in our previous study. The imaging system is in trans-illumination mode with a swept-wavelength laser and a CCD on a rotation gantry and the structural image from the X-ray computed tomography is used to guide and constrain the FT reconstruction algorithm. In this work, a phantom with two inclusions filled with different fluorophores is utilized to evaluate whether the spectral information obtained using sweptwavelength laser can distinguish these two inclusions. The images are captured from 8 different views with three different wavelengths.

Citation Download Citation

Pei-An Lo, Jaedu Cho, Farouk Nouizi, Huihua Kenny Chiang, and Gultekin Gulsen "Multispectral fluorescence diffuse optical tomography", Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560Z (14 March 2017); https://doi.org/10.1117/12.2251363

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KEYWORDS

Luminescence

Fourier transforms

Diffuse optical tomography

Absorption

CT reconstruction

Imaging systems

Near infrared

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