New contrasts for x-ray imaging and synergy with optical imaging

Ge Wang

doi:10.1117/12.2261456

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15 February 2017 New contrasts for x-ray imaging and synergy with optical imaging

Ge Wang

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Proceedings Volume 10057, Multimodal Biomedical Imaging XII; 100570K (2017) https://doi.org/10.1117/12.2261456
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Due to its penetrating power, fine resolution, unique contrast, high-speed, and cost-effectiveness, x-ray imaging is one of the earliest and most popular imaging modalities in biomedical applications. Current x-ray radiographs and CT images are mostly on gray-scale, since they reflect overall energy attenuation. Recent advances in x-ray detection, contrast agent, and image reconstruction technologies have changed our perception and expectation of x-ray imaging capabilities, and generated an increasing interest in imaging biological soft tissues in terms of energy-sensitive material decomposition, phase-contrast, small angle scattering (also referred to as dark-field), x-ray fluorescence and luminescence properties. These are especially relevant to preclinical and mesoscopic studies, and potentially mendable for hybridization with optical molecular tomography. In this article, we review new x-ray imaging techniques as related to optical imaging, suggest some combined x-ray and optical imaging schemes, and discuss our ideas on micro-modulated x-ray luminescence tomography (MXLT) and x-ray modulated opto-genetics (X-Optogenetics).

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Ge Wang "New contrasts for x-ray imaging and synergy with optical imaging", Proc. SPIE 10057, Multimodal Biomedical Imaging XII, 100570K (15 February 2017); https://doi.org/10.1117/12.2261456

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