A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

Mohsen Erfanzadeh; Michael Luciano; Feifei Zhou; Christian Brückner; Quing Zhu

doi:10.1117/12.2249877

3 March 2017 A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

Mohsen Erfanzadeh, Michael Luciano, Feifei Zhou, Christian Brückner, Quing Zhu

Author Affiliations +

Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 1006432 (2017) https://doi.org/10.1117/12.2249877
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

A PEGylated quinoline-annulated porphyrin derivative was synthesized as in vivo photoacoustic tomography contrast agent. It possesses high solubility and stability in water and phosphate-buffered saline. No toxicity sign was observed in BALB/c mice. The dye demonstrates a 4-fold higher photoacoustic signal generation efficiency compared to fresh rat blood. Injection of the dye results in a significant enhancement of in vivo PAT images of murine tumors. Analysis of the mouse urine after injection revealed an unaltered renal filtration of the contrast agent.

Citation Download Citation

Mohsen Erfanzadeh, Michael Luciano, Feifei Zhou, Christian Brückner, and Quing Zhu "A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006432 (3 March 2017); https://doi.org/10.1117/12.2249877

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