A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

Mohsen Erfanzadeh; Michael Luciano; Feifei Zhou; Christian Brückner; Quing Zhu

doi:10.1117/12.2249877

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3 March 2017 A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

Mohsen Erfanzadeh, Michael Luciano, Feifei Zhou, Christian Brückner, Quing Zhu

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Proceedings Volume 10064, Photons Plus Ultrasound: Imaging and Sensing 2017; 1006432 (2017) https://doi.org/10.1117/12.2249877
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

A PEGylated quinoline-annulated porphyrin derivative was synthesized as in vivo photoacoustic tomography contrast agent. It possesses high solubility and stability in water and phosphate-buffered saline. No toxicity sign was observed in BALB/c mice. The dye demonstrates a 4-fold higher photoacoustic signal generation efficiency compared to fresh rat blood. Injection of the dye results in a significant enhancement of in vivo PAT images of murine tumors. Analysis of the mouse urine after injection revealed an unaltered renal filtration of the contrast agent.

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Mohsen Erfanzadeh, Michael Luciano, Feifei Zhou, Christian Brückner, and Quing Zhu "A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006432 (3 March 2017); https://doi.org/10.1117/12.2249877

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