A lipid-based nano-regulator for cancer immunotherapy (Conference Presentation)

Yuan Qian; Sha Qiao; Zhihong Zhang

doi:10.1117/12.2251172

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19 April 2017 A lipid-based nano-regulator for cancer immunotherapy (Conference Presentation)

Yuan Qian, Sha Qiao, Zhihong Zhang

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Proceedings Volume 10065, Biophotonics and Immune Responses XII; 100650H (2017) https://doi.org/10.1117/12.2251172
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In the application of nanotechnology in cancer immunotherapy, antigen presenting cells (APCs, dendritic cells and macrophages) are preferable target due to their endocytic capacity and suppressed phenotype. Recently, we developed a lipid-based core-shell nanocarrier, which is stabilized by changeable fusion peptides and possesses a sub-30 diameter. With the different peptides, the nanoparticles (NPs) could either target to dendritic cells (DCs) in lymph nodes (LNs) or tumor associated macrophages (TAMs) in tumor environment. After subcutaneous injection, the NPs could targeted deliver the encapsulated antigen peptides (APs) and adjuvants (CpG-ODN) to dendritic cells in LNs, and lead to the antigen presenting and activation of cytotoxic T lymphocytes against tumor. In other case, after systemic administration, the immune regulatory molecules were carried by NPs and targeting delivered to specific immunocytes in tumor microenvironment resulting in the immunosuppressive state broken and tumor growth inhibition.

Conference Presentation

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Yuan Qian, Sha Qiao, and Zhihong Zhang "A lipid-based nano-regulator for cancer immunotherapy (Conference Presentation)", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 100650H (19 April 2017); https://doi.org/10.1117/12.2251172

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