Towards in vivo breast skin characterization using multiphoton microscopy

Ana Batista; Aisada Uchugonova; Hans Georg Breunig; Karsten König

doi:10.1117/12.2252387

21 February 2017 Towards in vivo breast skin characterization using multiphoton microscopy

Ana Batista, Aisada Uchugonova, Hans Georg Breunig, Karsten König

Proceedings Volume 10069, Multiphoton Microscopy in the Biomedical Sciences XVII; 100691Y (2017) https://doi.org/10.1117/12.2252387
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Breast cancer, the most common type of cancer in women worldwide, as well as its treatment (e.g. radiation therapy) can affect the human skin. Multiphoton imaging could provide new insights into these skin alterations non-invasively and with high-resolution. As a preparation for a later investigation involving patients, areas of the breast and forearm skin of healthy volunteers were imaged using the clinically certified multiphoton imaging tomograph MPTflex based on endogenous skin autofluorescence and second-harmonic signals. Depth-resolved image stacks were acquired in consecutive weeks to explore the influence of hormonal variations on the skin properties. Both breasts were considered and up to three different areas were imaged per session. Acquisition parameters were optimized to minimize artifacts caused by breathing-motion. As a first result, skin properties, such as the epidermal thickness, appear to be influenced by hormonal variations.

Citation Download Citation

Ana Batista, Aisada Uchugonova, Hans Georg Breunig, and Karsten König "Towards in vivo breast skin characterization using multiphoton microscopy", Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100691Y (21 February 2017); https://doi.org/10.1117/12.2252387

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KEYWORDS

Skin

Breast

In vivo imaging

Atrial fibrillation

Breast cancer

Second-harmonic generation

Cancer

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