In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion

Julia M. Pakela; Seung Yup Lee; Taylor L. Hedrick; Karthik Vishwanath; Michael C. Helton; Yooree G. Chung; Noah J. Kolodziejski; Christopher J. Staples; Daniel R. McAdams; Daniel E. Fernandez; James F. Christian; Jameson O'Reilly; Dana Farkas; Brent B. Ward; Stephen E. Feinberg; Mary-Ann Mycek

doi:10.1117/12.2252620

17 February 2017 In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion

Julia M. Pakela, Seung Yup Lee, Taylor L. Hedrick, Karthik Vishwanath, Michael C. Helton, Yooree G. Chung, Noah J. Kolodziejski, Christopher J. Staples, Daniel R. McAdams, Daniel E. Fernandez, James F. Christian, Jameson O'Reilly, Dana Farkas, Brent B. Ward, Stephen E. Feinberg, Mary-Ann Mycek

Author Affiliations +

Proceedings Volume 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics; 100720U (2017) https://doi.org/10.1117/12.2252620
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In reconstructive surgery, impeded blood flow in microvascular free flaps due to a compromise in arterial or venous patency secondary to blood clots or vessel spasms can rapidly result in flap failures. Thus, the ability to detect changes in microvascular free flaps is critical. In this paper, we report progress on in vivo pre-clinical testing of a compact, multimodal, fiber-based diffuse correlation and reflectance spectroscopy system designed to quantitatively monitor tissue perfusion in a porcine model’s surgically-grafted free flap. We also describe the device’s sensitivity to incremental blood flow changes and discuss the prospects for continuous perfusion monitoring in future clinical translational studies.

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Julia M. Pakela, Seung Yup Lee, Taylor L. Hedrick, Karthik Vishwanath, Michael C. Helton, Yooree G. Chung, Noah J. Kolodziejski, Christopher J. Staples, Daniel R. McAdams, Daniel E. Fernandez, James F. Christian, Jameson O'Reilly, Dana Farkas, Brent B. Ward, Stephen E. Feinberg, and Mary-Ann Mycek "In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion", Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 100720U (17 February 2017); https://doi.org/10.1117/12.2252620

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