Transcutaneous measurement of glomerular filtration rate in conscious laboratory animals: state of the art and future perspectives

Jochen Friedemann; Daniel Schock-Kusch; Yury Shulhevich

doi:10.1117/12.2250887

21 February 2017 Transcutaneous measurement of glomerular filtration rate in conscious laboratory animals: state of the art and future perspectives

Jochen Friedemann, Daniel Schock-Kusch, Yury Shulhevich

Author Affiliations +

Proceedings Volume 10079, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX; 100790J (2017) https://doi.org/10.1117/12.2250887
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Transcutaneous measurement of Glomerular Filtration Rate (tGFR) is now frequently used in preclinical in vivo animal studies. tGFR allows consecutive measurements on the same animal, including multiple measurements on a daily basis. A description of the measurement device and its many applications, along with examples from the recent literature will be given. We will highlight the fields of interest in which the system is used and give an overview about its performance versus endogenous and other exogenous methods of GFR measurement. A special focus will be put on the precision of tGFR compared to standard measurements employed in the research setting.

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Citation Download Citation

Jochen Friedemann, Daniel Schock-Kusch, and Yury Shulhevich "Transcutaneous measurement of glomerular filtration rate in conscious laboratory animals: state of the art and future perspectives", Proc. SPIE 10079, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX, 100790J (21 February 2017); https://doi.org/10.1117/12.2250887

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