Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip

Fusheng Zhao; Suyan Qiu; Jingting Li; Wei-Chuan Shih

doi:10.1117/12.2253011

17 February 2017 Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip

Fusheng Zhao, Suyan Qiu, Jingting Li, Wei-Chuan Shih

Proceedings Volume 10080, Plasmonics in Biology and Medicine XIV; 1008006 (2017) https://doi.org/10.1117/12.2253011
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Nanoplasmonic sensor has become a recent research focus due to its significant signal enhancement and robust signal transduction measured by various techniques. However, since the native gold surface does not have the capability to selectively bind target biomolecules, high molecular specificity has been a challenge. Nanoporous gold nanoparticle (NPG-NP) array chip showcases large specific surface area and high-density plasmonic field enhancement known as “hot-spots”. In this paper, we discuss strategies to enhance molecular specificity by functionalizing NPG-NP with unique bio-recognition elements towards both high sensitivity and specificity. A few examples will be given using existing and novel bio-recognition elements.

Conference Presentation

Citation Download Citation

Fusheng Zhao, Suyan Qiu, Jingting Li, and Wei-Chuan Shih "Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip", Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 1008006 (17 February 2017); https://doi.org/10.1117/12.2253011

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available