Contrast enhanced imaging with a stationary digital breast tomosynthesis system

Connor Puett; Jabari Calliste; Gongting Wu; Christina R. Inscoe; Yueh Z. Lee; Otto Zhou; Jianping Lu

doi:10.1117/12.2254348

9 March 2017 Contrast enhanced imaging with a stationary digital breast tomosynthesis system

Connor Puett, Jabari Calliste, Gongting Wu, Christina R. Inscoe, Yueh Z. Lee, Otto Zhou, Jianping Lu

Proceedings Volume 10132, Medical Imaging 2017: Physics of Medical Imaging; 1013225 (2017) https://doi.org/10.1117/12.2254348
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Digital breast tomosynthesis (DBT) captures some depth information and thereby improves the conspicuity of breast lesions, compared to standard mammography. Using contrast during DBT may also help distinguish malignant from benign sites. However, adequate visualization of the low iodine signal requires a subtraction step to remove background signal and increase lesion contrast. Additionally, attention to factors that limit contrast, including scatter, noise, and artifact, are important during the image acquisition and post-acquisition processing steps. Stationary DBT (sDBT) is an emerging technology that offers a higher spatial and temporal resolution than conventional DBT. This phantom-based study explored contrast-enhanced sDBT (CE sDBT) across a range of clinically-appropriate iodine concentrations, lesion sizes, and breast thicknesses. The protocol included an effective scatter correction method and an iterative reconstruction technique that is unique to the sDBT system. The study demonstrated the ability of this CE sDBT system to collect projection images adequate for both temporal subtraction (TS) and dual-energy subtraction (DES). Additionally, the reconstruction approach preserved the improved contrast-to-noise ratio (CNR) achieved in the subtraction step. Finally, scatter correction increased the iodine signal and CNR of iodine-containing regions in projection views and reconstructed image slices during both TS and DES. These findings support the ongoing study of sDBT as a potentially useful tool for contrast-enhanced breast imaging and also highlight the significant effect that scatter has on image quality during DBT.

Conference Presentation

Citation Download Citation

Connor Puett, Jabari Calliste, Gongting Wu, Christina R. Inscoe, Yueh Z. Lee, Otto Zhou, and Jianping Lu "Contrast enhanced imaging with a stationary digital breast tomosynthesis system", Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 1013225 (9 March 2017); https://doi.org/10.1117/12.2254348

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available