Fast frame rate rodent cardiac x-ray imaging using scintillator lens coupled to CMOS camera

Swathi Lakshmi B.; M.K.N. Sai Varsha; Ashwin Kumar N.; Madhulika Dixit; Ganapathy Krishnamurthi

doi:10.1117/12.2254541

9 March 2017 Fast frame rate rodent cardiac x-ray imaging using scintillator lens coupled to CMOS camera

Swathi Lakshmi B., M.K.N. Sai Varsha, Ashwin Kumar N., Madhulika Dixit, Ganapathy Krishnamurthi

Proceedings Volume 10132, Medical Imaging 2017: Physics of Medical Imaging; 101322K (2017) https://doi.org/10.1117/12.2254541
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Micro-Computed Tomography (MCT) systems for small animal imaging plays a critical role for monitoring disease progression and therapy evaluation. In this work, an in-house built micro-CT system equipped with a X-ray scintillator lens coupled to a commercial CMOS camera was used to test the feasibility of its application to Digital Subtraction Angiography (DSA). Literature has reported such studies being done with clinical X-ray tubes that can be pulsed rapidly or with rotating gantry systems, thus increasing the cost and infrastructural requirements.The feasibility of DSA was evaluated by injected Iodinated contrast agent (ICA) through the tail vein of a mouse. Projection images of the heart were acquired pre and post contrast using the high frame rate X-ray detector and processing done to visualize transit of ICA through the heart.

Citation Download Citation

Swathi Lakshmi B., M.K.N. Sai Varsha, Ashwin Kumar N., Madhulika Dixit, and Ganapathy Krishnamurthi "Fast frame rate rodent cardiac x-ray imaging using scintillator lens coupled to CMOS camera", Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101322K (9 March 2017); https://doi.org/10.1117/12.2254541

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