Spectroscopic properties of second generation photosensitizers for photo-diagnostics and photo-dynamic therapy

Magdalena Ligia Naurecka; Bartosz Michał Sierakowski; Mirosław Kwaśny

doi:10.1117/12.2261946

8 December 2016 Spectroscopic properties of second generation photosensitizers for photo-diagnostics and photo-dynamic therapy

Magdalena Ligia Naurecka, Bartosz Michał Sierakowski, Mirosław Kwaśny

Author Affiliations +

Proceedings Volume 10159, Laser Technology 2016: Progress and Applications of Lasers; 101590B (2016) https://doi.org/10.1117/12.2261946
Event: XIth Symposium on Laser Technology, 2016, Jastarnia, Poland

Abstract

The aim of the study was to investigate and compare photophysical properties of the most modern formulations used in the world – derivatives of: porphyrin, chlorines, bacteriochlorins, phthalocyanines and phenothiazines. Useful parameters of comparing the emission properties of various sensitizers groups are quantum yield of singlet oxygen generation (Φ_T) and quantum yields of fluorescence (Φ_F). The emission and excitation characteristics were appointed and shown as excitation – emission matrices (EX – EM). The influence of the monomerization degree of the pure hematoporphyrin (HP) on the quantum yield was also measured. Received quantum yield values of commonly used sensitizers are in the range 0.05 – 0.3 and efficiency values of singlet oxygen generation are 0.3 – 0.7. These values depend not only on the chemical structure of the compounds, but also on solvent polarity, temperature and concentration which is decisive for the monomerization degree.

Citation Download Citation

Magdalena Ligia Naurecka, Bartosz Michał Sierakowski, and Mirosław Kwaśny "Spectroscopic properties of second generation photosensitizers for photo-diagnostics and photo-dynamic therapy", Proc. SPIE 10159, Laser Technology 2016: Progress and Applications of Lasers, 101590B (8 December 2016); https://doi.org/10.1117/12.2261946

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