Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy

Yasumitsu Ishimaru; Yusuke Oshima; Yuuki Imai; Tadahiro Iimura; Sota Takanezawa; Kazunori Hino; Hiromasa Miura

doi:10.1117/12.2274980

18 April 2017 Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy

Yasumitsu Ishimaru, Yusuke Oshima, Yuuki Imai, Tadahiro Iimura, Sota Takanezawa, Kazunori Hino, Hiromasa Miura

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102511D (2017) https://doi.org/10.1117/12.2274980
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.

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Yasumitsu Ishimaru, Yusuke Oshima, Yuuki Imai, Tadahiro Iimura, Sota Takanezawa, Kazunori Hino, and Hiromasa Miura "Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511D (18 April 2017); https://doi.org/10.1117/12.2274980

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KEYWORDS

Bone

Raman spectroscopy

Nerve

Minerals

Animal model studies

Carbonates

Surgery

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