Light and ultrasound activated microbubbles around gold nanorods for photoacoustic microsurgery

Lucia Cavigli; Sonia Centi; Sarah Lai; Claudia Borri; Filippo Micheletti; Paolo Tortoli; Ilaria Panettieri; Ingolf Streit; Francesca Rossi; Fulvio Ratto; Roberto Pini

doi:10.1117/12.2286055

1 August 2017 Light and ultrasound activated microbubbles around gold nanorods for photoacoustic microsurgery

Lucia Cavigli, Sonia Centi, Sarah Lai, Claudia Borri, Filippo Micheletti, Paolo Tortoli, Ilaria Panettieri, Ingolf Streit, Francesca Rossi, Fulvio Ratto, Roberto Pini

Author Affiliations +

Proceedings Volume 10415, Opto-Acoustic Methods and Applications in Biophotonics III; 1041504 (2017) https://doi.org/10.1117/12.2286055
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

Photoacoustic imaging and microsurgery have recently attracted attention for applications in oncology. Here, we present a versatile set-up to trigger vapor microbubbles around plasmonic nanoparticles by a combined light-ultrasound excitation. This system enables the detection and parametrization of bubbles as a function of several variables, such us optical fluence, ultrasound intensity, nanoparticles concentration, thus providing useful directions to the development of new strategies for treatments based on optical cavitation.

Citation Download Citation

Lucia Cavigli, Sonia Centi, Sarah Lai, Claudia Borri, Filippo Micheletti, Paolo Tortoli, Ilaria Panettieri, Ingolf Streit, Francesca Rossi, Fulvio Ratto, and Roberto Pini "Light and ultrasound activated microbubbles around gold nanorods for photoacoustic microsurgery", Proc. SPIE 10415, Opto-Acoustic Methods and Applications in Biophotonics III, 1041504 (1 August 2017); https://doi.org/10.1117/12.2286055

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