Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy

Yi Hong Ong; Jonah Padawer-Curry; Jarod C. Finlay; Michele M. Kim; Andreea Dimofte; Keith Cengel; Timothy C. Zhu

doi:10.1117/12.2290727

5 March 2018 Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy

Yi Hong Ong, Jonah Padawer-Curry, Jarod C. Finlay, Michele M. Kim, Andreea Dimofte, Keith Cengel, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII; 104760Y (2018) https://doi.org/10.1117/12.2290727
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

PDT efficacy depends on the concentration of photosensitizer, oxygen, and light delivery in patient tissues. In this study, we measure the in-vivo distribution of important dosimetric parameters, namely the tissue optical properties (absorption μ_a (λ) and scattering μs ’ (λ) coefficients), photofrin concentration (cphotofrin), blood oxygen saturation (%S_tO₂), and total hemoglobin concentration (THC), before and after PDT. We characterize the inter- and intra-patient heterogeneity of these quantities and explore how these properties change as a result of PDT treatment. The result suggests the need for real-time dosimetry during PDT to optimize the treatment condition depending on the optical and physiological properties.

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Yi Hong Ong, Jonah Padawer-Curry, Jarod C. Finlay, Michele M. Kim, Andreea Dimofte, Keith Cengel, and Timothy C. Zhu "Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy", Proc. SPIE 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, 104760Y (5 March 2018); https://doi.org/10.1117/12.2290727

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