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14 March 2018 Cryo-micro-optical sectioning tomography for label-free brainwide visualization of senile plaque (Conference Presentation)
Yilin Luo, Anle Wang, Mengmeng Liu, Tian Lei, Xiaochuan Zhang, Zhaobing Gao, Hualiang Liang, Hui Gong, Jing Yuan
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Proceedings Volume 10481, Neural Imaging and Sensing 2018; 104810M (2018) https://doi.org/10.1117/12.2296253
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
Optical visualization of Alzheimer’s disease (AD) pathological changes is crucial to facilitate exploration of disease mechanism and treatment. We developed cryo-micro-optical sectioning tomography (cryo-MOST) to acquire brainwide map of senile plaques. Using intrinsic fluorescence emission intensified under ultra-low temperature, we accomplished senile plaque visualization at a micron-level resolution. A whole-brain coronal distribution of senile plaque in a transgenic mouse was successfully acquired without any exogenous dye. We believe cryo-MOST would be a potential tool for understanding neurodegenerative disease mechanism and evaluating drug efficacy.
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Yilin Luo, Anle Wang, Mengmeng Liu, Tian Lei, Xiaochuan Zhang, Zhaobing Gao, Hualiang Liang, Hui Gong, and Jing Yuan "Cryo-micro-optical sectioning tomography for label-free brainwide visualization of senile plaque (Conference Presentation)", Proc. SPIE 10481, Neural Imaging and Sensing 2018, 104810M (14 March 2018); https://doi.org/10.1117/12.2296253
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KEYWORDS
Visualization
Tomography
Alzheimer's disease
Brain mapping
Luminescence
Visual optics
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