Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)

Kelsey C. Leeburg; Mohamed T. El-Haddad; Joseph D. Malone; Benjamin D. Terrones; Yuankai K. Tao

doi:10.1117/12.2292132

14 February 2018 Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)

Kelsey C. Leeburg, Mohamed T. El-Haddad, Joseph D. Malone, Benjamin D. Terrones, Yuankai K. Tao

Author Affiliations +

Proceedings Volume 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII; 1048306 (2018) https://doi.org/10.1117/12.2292132
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Scanning laser ophthalmoscopy (SLO) provides high-speed, noninvasive en face imaging of the retinal fundus. Optical coherence tomography (OCT) is the current “gold-standard” for ophthalmic diagnostic imaging and enables depth-resolved visualization of ophthalmic structures and image-based surrogate biomarkers of disease. We present a compact optical and mechanical design for handheld spectrally encoded coherence tomography and reflectometry (SECTR) for multimodality en face spectrally encoded reflectometry (SER) and cross-sectional OCT imaging. We custom-designed a double-pass telecentric scan lens, which halves the size of 4-f optical relays and allowed us to reduce the footprint of our SECTR scan-head by a factor of >2.7x (volume) over our previous design. The double-pass scan lens was optimized for diffraction-limited performance over a ±10° scan field. SECTR optics and optomechanics were combined in a compact rapid-prototyped enclosure with dimensions 87 x 141.8 x 137 mm (w x h x d). SECTR was implemented using a custom-built 400 kHz 1050 nm swept-source. OCT and SER were simultaneously digitized on dual input channels of a 4 GS/s digitizer at 1.4 GS/s per channel. In vivo human en face SER and cross-sectional OCT images were acquired at 350 fps. OCT volumes of 1000 B-scans were acquired in 2.86 s. We believe clinical translation of our compact handheld design will benefit point-of-care ophthalmic diagnostics in patients who are unable to be imaged on conventional slit-lamp based systems, such as infants and the bedridden. When combined with multi-volumetric registration methods, handheld SECTR will have advantages in motion-artifact free imaging over existing handheld technologies.

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Kelsey C. Leeburg, Mohamed T. El-Haddad, Joseph D. Malone, Benjamin D. Terrones, and Yuankai K. Tao "Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)", Proc. SPIE 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII, 1048306 (14 February 2018); https://doi.org/10.1117/12.2292132

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KEYWORDS

Optical coherence tomography

Ophthalmic imaging

Reflectometry

Relays

Retinal scanning

Coherence (optics)

Scanning laser ophthalmoscopy

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