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14 March 2018 Fabricating and characterizing long lived tissue phantoms using intralipid-infused solids
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Abstract
The creation of stable test phantoms that mimic the scattering characteristics of biological tissue is important for characterizing different Optical imaging methods through biological tissue. Unfortunately utilizing organic materials as tissue test structures pose problems in biomedical imaging research; tissues tend to have short lifetime, change their scattering and other optical characteristics rapidly with time, and are difficult to uses as reliable standards for comparing calibrating imaging systems. To solve these problems ongoing work has shown it is technically possible to create long term stable phantoms which can last for up to 5 years while maintaining consistent optical characteristics which mimic skin characteristics. These long term test phantom is created by encapsulating an intralipid-infused agar layer within clear polymer. Varying the intralipid concentration allows control of the scattering parameters with typical values of µs = 20cm-1, g = 0.95. The phantoms can be created in a wide range of thicknesses and shapes. To characterize these we developed a technique using a digitial camera to capture, in a single measurement, the scattered light from laser beams passing through the test phantoms. Analysis of the image allows hundreds of measurements of scattering values at a wide range of angles using a Matlab program to identify the scattering center and the angular positions. We fitted this to scattering models to extract the µs and g parameters for each test phantom Consistent results were obtained using a Henyey-Greenstein two-term model, probably because the Agar and intralipid impacted the scattering separately.
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Glenn H. Chapman and Peter Le "Fabricating and characterizing long lived tissue phantoms using intralipid-infused solids ", Proc. SPIE 10492, Optical Interactions with Tissue and Cells XXIX, 104920N (14 March 2018); https://doi.org/10.1117/12.2291414
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