Quantification of amyloid deposits and oxygen extraction fraction in the brain with multispectral optoacoustic imaging in arcAbeta mouse model of Alzheimer's disease

Ruiqing Ni; Markus Vaas; Markus Rudin; Jan Klohs

doi:10.1117/12.2286309

19 February 2018 Quantification of amyloid deposits and oxygen extraction fraction in the brain with multispectral optoacoustic imaging in arcAβ mouse model of Alzheimer's disease

Ruiqing Ni, Markus Vaas, Markus Rudin, Jan Klohs

Author Affiliations +

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 104941G (2018) https://doi.org/10.1117/12.2286309
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Beta-amyloid (Aβ) deposition and vascular dysfunction are important contributors to the pathogenesis in Alzheimer’s disease (AD). However, the spatio-temporal relationship between an altered oxygen metabolism and Aβ deposition in the brain remains elusive. Here we provide novel in-vivo estimates of brain Aβ load with Aβ-binding probe CRANAD-2 and measures of brain oxygen saturation by using multi-spectral optoacoustic imaging (MSOT) and perfusion imaging with magnetic resonance imaging (MRI) in arcAβ mouse models of AD. We demonstrated a decreased cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO₂) in the cortical region of the arcAβ mice compared to wildtype littermates at 24 months. In addition, we showed proof-of-concept for the detection of cerebral Aβ deposits in brain from arcAβ mice compared to wild-type littermates.

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Citation Download Citation

Ruiqing Ni, Markus Vaas, Markus Rudin, and Jan Klohs "Quantification of amyloid deposits and oxygen extraction fraction in the brain with multispectral optoacoustic imaging in arcAβ mouse model of Alzheimer's disease", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104941G (19 February 2018); https://doi.org/10.1117/12.2286309

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