Photoacoustic microscopy imaging for microneedle drug delivery

Mohesh Moothanchery; Razina Z. Seeni; Chenjie Xu; Manojit Pramanik

doi:10.1117/12.2287837

19 February 2018 Photoacoustic microscopy imaging for microneedle drug delivery

Mohesh Moothanchery, Razina Z. Seeni, Chenjie Xu, Manojit Pramanik

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 104945P (2018) https://doi.org/10.1117/12.2287837
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

The recent development of novel transdermal drug delivery systems (TDDS) using microneedle technology allows micron-sized conduits to be formed within the outermost skin layers attracting keen interest in skin as an interface for localized and systemic delivery of therapeutics. In light of this, researchers are using microneedles as tools to deliver nanoparticle formulations to targeted sites for effective therapy. However, in such studies the use of traditional histological methods are employed for characterization and do not allow for the in vivo visualization of drug delivery mechanism. Hence, this study presents a novel imaging technology to characterize microneedle based nanoparticle delivery systems using optical resolution-photoacoustic microscopy (OR-PAM). In this study in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and the spatial distribution of the nanoparticles in the tissue was successfully illustrated. Characterization of parameters that are relevant in drug delivery studies such as penetration depth, efficiency of delivered gold nanoparticles were monitored using the system. Photoacoustic microscopy proves an ideal tool for the characterization studies of microneedle properties and the studies shows microneedles as an ideal tool for precise and controlled drug delivery.

Citation Download Citation

Mohesh Moothanchery, Razina Z. Seeni, Chenjie Xu, and Manojit Pramanik "Photoacoustic microscopy imaging for microneedle drug delivery", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104945P (19 February 2018); https://doi.org/10.1117/12.2287837

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Manganese

Skin

Nanoparticles

In vivo imaging

Ear

Photoacoustic microscopy

Photoacoustic imaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years