Computational study for optimization of a plasmon FET as a molecular biosensor

Mark Ciappesoni; Seongman Cho; Jieyuan Tian; Sung Jin Kim

doi:10.1117/12.2288041

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20 February 2018 Computational study for optimization of a plasmon FET as a molecular biosensor

Mark Ciappesoni, Seongman Cho, Jieyuan Tian, Sung Jin Kim

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Proceedings Volume 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV; 105060T (2018) https://doi.org/10.1117/12.2288041
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Surface Plasmon Resonance (SPR) is currently being widely studied as it exhibits sensitive optical properties to changes in in the refractive index of the surrounding medium. As novel devices using SPR have been developing rapidly there is a necessity to develop models and simulation environments that will allow for continued development and optimization of these devices. A biological sensing device of interest is the Plasmon FET which has been proven experimentally to have a limit of detection (LOD) of 20pg/ml while being immune to the absorption of the medium. The Plasmon FET is a metal-semiconductor-metal detector which employ functionalized gold nanostructures on a semi-conducting layer. This direct approach has the advantages of not requiring readout optics reducing size and allowing for point-of -care measurements. Using Lumerical FDTD and Device numerical solvers, we can report an advanced simulation environment illustrating several key sensor specifications including LOD, resolution, sensitivity, and dynamic range, for a variety of biological markers providing a comprehensive analysis of a Direct Plasmon-to-Electric conversion device designed to function with colored mediums (eg.whole blood). This model allows for the simulation and optimization of a plasmonic sensor that already o ers advantages in size, operability, and multiplexing-capability, with real time monitoring.

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Mark Ciappesoni, Seongman Cho, Jieyuan Tian, and Sung Jin Kim "Computational study for optimization of a plasmon FET as a molecular biosensor ", Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 105060T (20 February 2018); https://doi.org/10.1117/12.2288041

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