Fabrication of flexible microporous 3D scaffolds via stereolithography and optimization of their biocompatibility

Giedre Grigalevičiūtė; Daiva Baltriukienė; Evaldas Balčiūnas; Linas Jonušauskas; Mangirdas Malinauskas

doi:10.1117/12.2288291

22 February 2018 Fabrication of flexible microporous 3D scaffolds via stereolithography and optimization of their biocompatibility

Giedre Grigalevičiūtė, Daiva Baltriukienė, Evaldas Balčiūnas, Linas Jonušauskas, Mangirdas Malinauskas

Author Affiliations +

Proceedings Volume 10544, Advanced Fabrication Technologies for Micro/Nano Optics and Photonics XI; 105441E (2018) https://doi.org/10.1117/12.2288291
Event: SPIE OPTO, 2018, San Francisco, California, United States

Abstract

In this work the principles of fabrication of 3D scaffolds via stereolithography and scaffolds’ biocompatibility are investigated. Cells can be seeded into 3D printer-formed structures and artificial tissue or organ can be grown and implanted into human body. In this work the requirements of reproducing the original environment of cells in such bioscaffolds are used in order to create and test mechanically flexible microporous structures. New materials and suitable scaffolds’ geometries might bring desired features in tissue engineering. The scaffolds were fabricated using the tabletop 3D printer Autodesk Ember. Commercial photoresin Formlabs Flexible was used for this task. Optimization steps presented in this paper allowed to increase the biocompabaility of the scaffolds by 48% in comparison to unoptimized ones.

Citation Download Citation

Giedre Grigalevičiūtė, Daiva Baltriukienė, Evaldas Balčiūnas, Linas Jonušauskas, and Mangirdas Malinauskas "Fabrication of flexible microporous 3D scaffolds via stereolithography and optimization of their biocompatibility", Proc. SPIE 10544, Advanced Fabrication Technologies for Micro/Nano Optics and Photonics XI, 105441E (22 February 2018); https://doi.org/10.1117/12.2288291

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