Quantifying expert diagnosis variability when grading tumor-infiltrating lymphocytes

Paula Toro; Germán Corredor; Xiangxue Wang; Viviana Arias; Vamsidhar Velcheti; Anant Madabhushi; Eduardo Romero

doi:10.1117/12.2286717

17 November 2017 Quantifying expert diagnosis variability when grading tumor-infiltrating lymphocytes

Paula Toro, Germán Corredor, Xiangxue Wang, Viviana Arias, Vamsidhar Velcheti, Anant Madabhushi, Eduardo Romero

Proceedings Volume 10572, 13th International Conference on Medical Information Processing and Analysis; 1057202 (2017) https://doi.org/10.1117/12.2286717
Event: 13th International Symposium on Medical Information Processing and Analysis, 2017, San Andres Island, Colombia

Abstract

Tumor-infiltrating lymphocytes (TILs) have proved to play an important role in predicting prognosis, survival, and response to treatment in patients with a variety of solid tumors. Unfortunately, currently, there are not a standardized methodology to quantify the infiltration grade. The aim of this work is to evaluate variability among the reports of TILs given by a group of pathologists who examined a set of digitized Non-Small Cell Lung Cancer samples (n=60). 28 pathologists answered a different number of histopathological images. The agreement among pathologists was evaluated by computing the Kappa index coefficient and the standard deviation of their estimations. Furthermore, TILs reports were correlated with patient’s prognosis and survival using the Pearson’s correlation coefficient. General results show that the agreement among experts grading TILs in the dataset is low since Kappa values remain below 0.4 and the standard deviation values demonstrate that in none of the images there was a full consensus. Finally, the correlation coefficient for each pathologist also reveals a low association between the pathologists’ predictions and the prognosis/survival data. Results suggest the need of defining standardized, objective, and effective strategies to evaluate TILs, so they could be used as a biomarker in the daily routine.

Citation Download Citation

Paula Toro, Germán Corredor, Xiangxue Wang, Viviana Arias, Vamsidhar Velcheti, Anant Madabhushi, and Eduardo Romero "Quantifying expert diagnosis variability when grading tumor-infiltrating lymphocytes", Proc. SPIE 10572, 13th International Conference on Medical Information Processing and Analysis, 1057202 (17 November 2017); https://doi.org/10.1117/12.2286717

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KEYWORDS

Tumors

Pathology

Lung cancer

Cancer

Human-machine interfaces

Image quality

Oncology

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