A novel framework for the local extraction of extra-axial cerebrospinal fluid from MR brain images

Mahmoud Mostapha; Mark D. Shen; SunHyung Kim; Meghan Swanson; D. Louis Collins; Vladimir Fonov; Guido Gerig; Joseph Piven; Martin A. Styner

doi:10.1117/12.2293116

2 March 2018 A novel framework for the local extraction of extra-axial cerebrospinal fluid from MR brain images

Mahmoud Mostapha, Mark D. Shen, SunHyung Kim, Meghan Swanson, D. Louis Collins, Vladimir Fonov, Guido Gerig, Joseph Piven, Martin A. Styner

Author Affiliations +

Proceedings Volume 10574, Medical Imaging 2018: Image Processing; 105740V (2018) https://doi.org/10.1117/12.2293116
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

The quantification of cerebrospinal fluid (CSF) in the human brain has shown to play an important role in early postnatal brain developmental. Extr a-axial fluid (EA-CSF), which is characterized by the CSF in the subarachnoid space, is promising in the early detection of children at risk for neurodevelopmental disorders. Currently, though, there is no tool to extract local EA-CSF measurements in a way that is suitable for localized analysis. In this paper, we propose a novel framework for the localized, cortical surface based analysis of EA-CSF. In our proposed processing, we combine probabilistic brain tissue segmentation, cortical surface reconstruction as well as streamline based local EA-CSF quantification. For streamline computation, we employ the vector field generated by solving a Laplacian partial differential equation (PDE) between the cortical surface and the outer CSF hull. To achieve sub-voxel accuracy while minimizing numerical errors, fourth-order Runge-Kutta (RK4) integration was used to generate the streamlines. Finally, the local EA-CSF is computed by integrating the CSF probability along the generated streamlines. The proposed local EA-CSF extraction tool was used to study the early postnatal brain development in typically developing infants. The results show that the proposed localized EA-CSF extraction pipeline can produce statistically significant regions that are not observed in previous global approach.

Conference Presentation

Citation Download Citation

Mahmoud Mostapha, Mark D. Shen, SunHyung Kim, Meghan Swanson, D. Louis Collins, Vladimir Fonov, Guido Gerig, Joseph Piven, and Martin A. Styner "A novel framework for the local extraction of extra-axial cerebrospinal fluid from MR brain images", Proc. SPIE 10574, Medical Imaging 2018: Image Processing, 105740V (2 March 2018); https://doi.org/10.1117/12.2293116

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available