Deformable registration of radiation isodose lines to delayed contrast-enhanced magnetic resonance images for assessment of myocardial lesion formation following proton beam therapy

M. E. Rettmann; A. Suzuki; A. J. Deisher; S. Wang; S. Hohmann; H. Konishi; H. I. Lehmann; J. J. Kruse; J. T. Cusma; L. K. Newman; K. D. Parker; M. G. Herman; D. L. Packer

doi:10.1117/12.2295439

22 March 2018 Deformable registration of radiation isodose lines to delayed contrast-enhanced magnetic resonance images for assessment of myocardial lesion formation following proton beam therapy

M. E. Rettmann, A. Suzuki, A. J. Deisher, S. Wang, S. Hohmann, H. Konishi, H. I. Lehmann, J. J. Kruse, J. T. Cusma, L. K. Newman, K. D. Parker, M. G. Herman, D. L. Packer

Author Affiliations +

Proceedings Volume 10576, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling; 105760G (2018) https://doi.org/10.1117/12.2295439
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

Ventricular tachycardia is increasingly treated with ablation therapy, a technique in which catheters are guided into the ventricle and radiofrequency energy is delivered into the myocardial tissue to interrupt arrhythmic electrical pathways. Recent efforts have investigated the use of noninvasive external beam therapy for treatment of ventricular tachycardia where target regions are identified in the myocardium and treated using external beams. The relationship between the planned dose map and myocardial tissue change, however, has not yet been quantified. In this work, we use a deformable registration algorithm to align dose maps planned from baseline computed-tomography scans to delayed contrast-enhanced magnetic resonance imaging scans taken at 4 week intervals following proton beam therapy. From this data, the relationship between the planned dose and image enhancement, which serves as a surrogate for tissue change, can be quantified.

Citation Download Citation

M. E. Rettmann, A. Suzuki, A. J. Deisher, S. Wang, S. Hohmann, H. Konishi, H. I. Lehmann, J. J. Kruse, J. T. Cusma, L. K. Newman, K. D. Parker, M. G. Herman, and D. L. Packer "Deformable registration of radiation isodose lines to delayed contrast-enhanced magnetic resonance images for assessment of myocardial lesion formation following proton beam therapy", Proc. SPIE 10576, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling, 105760G (22 March 2018); https://doi.org/10.1117/12.2295439

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available