Ultrasound, elasticity, and photoacoustic imaging of cervix: towards a more accurate prediction of preterm delivery (Conference Presentation)

Yan Yan; Jiayin Dong; Adeel A. Siddiqu; Yashashree Majalikar; Maryam Basij; Edgar Hernandez-Andrade; Sonia Hassan; Mohammad Mehrmohammadi

doi:10.1117/12.2296469

14 March 2018 Ultrasound, elasticity, and photoacoustic imaging of cervix: towards a more accurate prediction of preterm delivery (Conference Presentation)

Yan Yan, Jiayin Dong, Adeel A. Siddiqu, Yashashree Majalikar, Maryam Basij, Edgar Hernandez-Andrade, Sonia Hassan, Mohammad Mehrmohammadi

Author Affiliations +

Proceedings Volume 10580, Medical Imaging 2018: Ultrasonic Imaging and Tomography; 105800U (2018) https://doi.org/10.1117/12.2296469
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

Spontaneous preterm birth (sPTB) occurs in about one in ten infants born in the United States and is leading to almost 1 million neonatal deaths worldwide [1]. Diagnostic imaging of cervix is mostly limited to using ultrasound (US) to measure cervical length and has shown a low specificity to determine the risk of sPTB [2-7]. Quantitative functional imaging modalities such as elastography (EL) and photoacoustic (PA) imaging, are commonly used in conjunction with US imaging to provide additional information on tissue compositions and function. We propose using an endocavity probe to acquire US, PA, and EL information of the cervical tissue. Specifically, spectroscopic PA (sPA) is proposed to provide information on cervical tissue such as total hemoglobin (blood perfusion), tissue oxygenation level, and more importantly the collagen-to-water ratio in tissue. Shear wave elastography (SWE) measurements of cervical tissue indicates the correlation between cervical ripening and lower tissue elasticity. Our custom-designed imaging system consists of an endovaginal US transducer (ATL C9-5) capable of performing high frame rate US and acoustic radiation force shear wave imaging, and an optimized fiber-optic light delivery system’s for PA imaging. Our experimental results indicate the system’s ability to measure the presence of different concentrations of hemoglobin in tissue-mimicking phantoms as well as accurate measurement of hemoglobin oxygen saturation (SO2). In another set of experiments, we demonstrated the feasibility of monitoring collagen-to-water ratio in tissues through monitoring changes in sPA signature between 1100 and 1650 nm. Monitoring the variations of collagen in cervical tissue can help to predict sPTB.

Conference Presentation

Citation Download Citation

Yan Yan, Jiayin Dong, Adeel A. Siddiqu, Yashashree Majalikar, Maryam Basij, Edgar Hernandez-Andrade, Sonia Hassan, and Mohammad Mehrmohammadi "Ultrasound, elasticity, and photoacoustic imaging of cervix: towards a more accurate prediction of preterm delivery (Conference Presentation)", Proc. SPIE 10580, Medical Imaging 2018: Ultrasonic Imaging and Tomography, 105800U (14 March 2018); https://doi.org/10.1117/12.2296469

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available