Application of fluorescent and vibration spectroscopy for septic serum human albumin structure deformation during pathology

A. Zyubin; E. Konstantinova; V. Slezhkin; K. Matveeva; I. Samusev; V. Bryukhanov

doi:10.1117/12.2295315

7 December 2017 Application of fluorescent and vibration spectroscopy for septic serum human albumin structure deformation during pathology

A. Zyubin, E. Konstantinova, V. Slezhkin, K. Matveeva, I. Samusev, V. Bryukhanov

Author Affiliations +

Proceedings Volume 10592, Biophotonics—Riga 2017; 1059205 (2017) https://doi.org/10.1117/12.2295315
Event: The Second International Conference "Biophotonics-Riga 2017", 2017, Riga, Latvia

Abstract

In this paper we perform results of conformational analysis of septic human serum albumin (HSA) carried out by Raman spectroscopy (RS), infrared (IR) spectroscopy and fluorescent spectroscopy. The main vibrational groups were identified and analyzed for septic HSA and its health control. Comparison between Raman and IR results were done. Fluorescent spectral changes of Trp-214 group were analyzed. Application of Raman, IR spectroscopy, fluorescent spectroscopy for conformational changes study of HSA during pathology were shown.

Citation Download Citation

A. Zyubin, E. Konstantinova, V. Slezhkin, K. Matveeva, I. Samusev, and V. Bryukhanov "Application of fluorescent and vibration spectroscopy for septic serum human albumin structure deformation during pathology", Proc. SPIE 10592, Biophotonics—Riga 2017, 1059205 (7 December 2017); https://doi.org/10.1117/12.2295315

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