Probing tissue multifractality for optical diagnosis of diabetic retinopathy

Sawon Pratiher; Sabyasachi Mukhopadhyay; Sukanya Mukherjee; Ritwik Barman; Gautham Pasupuleti; Jay Chhablani; Prasanta K. Panigrahi

doi:10.1117/12.2305454

24 May 2018 Probing tissue multifractality for optical diagnosis of diabetic retinopathy

Sawon Pratiher, Sabyasachi Mukhopadhyay, Sukanya Mukherjee, Ritwik Barman, Gautham Pasupuleti, Jay Chhablani, Prasanta K. Panigrahi

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Proceedings Volume 10679, Optics, Photonics, and Digital Technologies for Imaging Applications V; 1067906 (2018) https://doi.org/10.1117/12.2305454
Event: SPIE Photonics Europe, 2018, Strasbourg, France

Abstract

Diabetic Retinopathy (DR) is one of the most dominant diseases across the globe which causes blindness. In this manuscript, we have probed tissue multifractality in order to identify the submicron level changes in medium refractive indices due to progress of diabetic retinopathy from mild to severe stages. Hence the quantification of multifractal parameters like Hurst exponent (measurement of correlation) and width of singularity (measurement of heterogeneity) have been executed. As we proceed from healthy to different stages (mild, moderate and severe) of diabetic retinopathy, there are decrement of Hurst exponent value, whereas, width of singularity spectrum increases. In general, the use of multifractal analysis on in vivo diabetic retinopathy images lead to a diagnostic modality as a potential statistical biomarker.

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Sawon Pratiher, Sabyasachi Mukhopadhyay, Sukanya Mukherjee, Ritwik Barman, Gautham Pasupuleti, Jay Chhablani, and Prasanta K. Panigrahi "Probing tissue multifractality for optical diagnosis of diabetic retinopathy ", Proc. SPIE 10679, Optics, Photonics, and Digital Technologies for Imaging Applications V, 1067906 (24 May 2018); https://doi.org/10.1117/12.2305454

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KEYWORDS

Tissue optics

Tissues

In vivo imaging

Data analysis

Statistical analysis

Eye

Refractive index

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