The light collected from remote sensors taken from space must transit through the Earth’s atmosphere. All satellite images are affected at some level by lightwave scattering and absorption from aerosols, water vapor and particulates in the atmosphere. For generating high-quality scientific data, atmospheric correction is required to remove atmospheric effects and to convert digital number (DN) values to surface reflectance (SR). Every optical satellite in orbit observes the earth through the same atmosphere, but each satellite image is impacted differently because atmospheric conditions are constantly changing. A physics-based detailed radiative transfer model 6SV requires a lot of key ancillary information about the atmospheric conditions at the acquisition time. This paper investigates to achieve the simultaneous acquisition of atmospheric radiation parameters based on the multi-spectral information, in order to improve the estimates of surface reflectance through physics-based atmospheric correction. Ancillary information on the aerosol optical depth (AOD) and total water vapor (TWV) derived from the multi-spectral information based on specific spectral properties was used for the 6SV model. The experimentation was carried out on images of Sentinel-2, which carries a Multispectral Instrument (MSI), recording in 13 spectral bands, covering a wide range of wavelengths from 440 up to 2200 nm. The results suggest that per-pixel atmospheric correction through 6SV model, integrating AOD and TWV derived from multispectral information, is better suited for accurate analysis of satellite images and quantitative remote sensing application.