Application of virtual phase-shifting speckle-interferometry for detection of polymorphism in the Chlamydia trachomatis omp1 gene

Valentina A. Feodorova; Yury V. Saltykov; Sergey S. Zaytsev; Sergey S. Ulyanov; Onega V. Ulianova

doi:10.1117/12.2314700

26 April 2018 Application of virtual phase-shifting speckle-interferometry for detection of polymorphism in the Chlamydia trachomatis omp1 gene

Valentina A. Feodorova, Yury V. Saltykov , Sergey S. Zaytsev, Sergey S. Ulyanov, Onega V. Ulianova

Author Affiliations +

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107160M (2018) https://doi.org/10.1117/12.2314700
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

Method of phase-shifting speckle-interferometry has been used as a new tool with high potency for modern bioinformatics. Virtual phase-shifting speckle-interferometry has been applied for detection of polymorphism in the of Chlamydia trachomatis omp1 gene. It has been shown, that suggested method is very sensitive to natural genetic mutations as single nucleotide polymorphism (SNP). Effectiveness of proposed method has been compared with effectiveness of the newest bioinformatic tools, based on nucleotide sequence alignment.

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Valentina A. Feodorova, Yury V. Saltykov , Sergey S. Zaytsev, Sergey S. Ulyanov, and Onega V. Ulianova "Application of virtual phase-shifting speckle-interferometry for detection of polymorphism in the Chlamydia trachomatis omp1 gene", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160M (26 April 2018); https://doi.org/10.1117/12.2314700

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