Detection of the presence of Chlamydia trachomatis bacteria using diffusing wave spectroscopy with a small number of scatterers

Sergey Ulyanov; Onega Ulianova; Nadezhda Filonova; Yulia Moiseeva; Sergey Zaitsev; Yury Saltykov; Tatiana Polyanina; Anna Lyapina; Irina Kalduzova; Olga Larionova; Sergey Utz; Valentina Feodorova

doi:10.1117/12.2314570

26 April 2018 Detection of the presence of Chlamydia trachomatis bacteria using diffusing wave spectroscopy with a small number of scatterers

Sergey Ulyanov, Onega Ulianova, Nadezhda Filonova, Yulia Moiseeva, Sergey Zaitsev, Yury Saltykov, Tatiana Polyanina, Anna Lyapina, Irina Kalduzova, Olga Larionova, Sergey Utz, Valentina Feodorova

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Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107160O (2018) https://doi.org/10.1117/12.2314570
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

Theory of diffusing wave spectroscopy has been firstly adapted to the problem of rapid detection of Chlamydia trachomatis bacteria in blood samples of Chlamydia patients. Formula for correlation function of temporal fluctuations of speckle intensity is derived for the case of small number of scattering events. Dependence of bandwidth of spectrum on average number of scatterers is analyzed. Set-up for detection of the presence of C. trachomatis cells in aqueous suspension is designed. Good agreement between theoretical results and experimental data is shown. Possibility of detection of the presence of C. trachomatis cells in probing volume using diffusing wave spectroscopy with a small number of scatterers is successfully demonstrated for the first time.

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Sergey Ulyanov, Onega Ulianova, Nadezhda Filonova, Yulia Moiseeva, Sergey Zaitsev, Yury Saltykov, Tatiana Polyanina, Anna Lyapina, Irina Kalduzova, Olga Larionova, Sergey Utz, and Valentina Feodorova "Detection of the presence of Chlamydia trachomatis bacteria using diffusing wave spectroscopy with a small number of scatterers", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160O (26 April 2018); https://doi.org/10.1117/12.2314570

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