System of 3D Mueller-matrix reconstruction of fibrillar networks of biological tissues of various morphological structure and physiological state

Yu. A. Ushenko; A. V. Syvokorovskaya; M. P. Gorsky; Yu. A. Tomka; S. O. Sokolnuik; O. Bakun; L. Yu. Kushnerik; S. Golub; R. Besaga

doi:10.1117/12.2320535

5 September 2018 System of 3D Mueller-matrix reconstruction of fibrillar networks of biological tissues of various morphological structure and physiological state

Yu. A. Ushenko, A. V. Syvokorovskaya, M. P. Gorsky, Yu. A. Tomka, S. O. Sokolnuik, O. Bakun, L. Yu. Kushnerik, S. Golub, R. Besaga

Author Affiliations +

Proceedings Volume 10728, Biosensing and Nanomedicine XI; 107280R (2018) https://doi.org/10.1117/12.2320535
Event: SPIE Nanoscience + Engineering, 2018, San Diego, California, United States

Abstract

The method of azimuthally invariant 3D Muller-matrix mapping of distributions of phase and amplitude anisotropy parameters of partially depolarizing layers of biological tissues of different morphological structures is proposed and substantiated. In the volume of biological samples, the coordinate distributions of the magnitude of the set of Mullermatrix invariants (MMI) histological sections of the myocardium tissue with a spatially structured optical anisotropic fibrillary network, as well as parenchymal tissue of the rat liver with an islet polycrystalline structure, were obtained. The "phase" dependences of the magnitude of the statistical moments of the 1 st - 4 th orders, which characterize the distributions of the MMI values of polarization manifestations of the parameters of linear and circular birefringence and dichroism of the polycrystalline component of different types of biological tissues, are determined. A comparative study was made of the possibilities of differentiation of changes in the parameters of optical anisotropy using traditional 2D and 3D Muller-matrix mapping methods. The optimal conditions for the differentiation of polycrystalline structures of biological tissues - the range of phase sections and the most sensitive parameters - are the statistical moments of the 3rd and 4th orders that characterize the distributions of MMI associated with the polarization manifestations of linear birefringence and dichroism of different types of optically anisotropic structures.

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Yu. A. Ushenko, A. V. Syvokorovskaya, M. P. Gorsky, Yu. A. Tomka, S. O. Sokolnuik, O. Bakun, L. Yu. Kushnerik, S. Golub, and R. Besaga "System of 3D Mueller-matrix reconstruction of fibrillar networks of biological tissues of various morphological structure and physiological state", Proc. SPIE 10728, Biosensing and Nanomedicine XI, 107280R (5 September 2018); https://doi.org/10.1117/12.2320535

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