Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer

Jian Zou; Jie Jiang; Zhen Han; Lisheng Lin; Yongzhen Li; Zheng Huang

doi:10.1117/12.2502481

23 October 2018 Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer

Jian Zou, Jie Jiang, Zhen Han, Lisheng Lin, Yongzhen Li, Zheng Huang

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108203C (2018) https://doi.org/10.1117/12.2502481
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Photodynamic therapy (PDT) utilizes the combined action of photosensitizer, light and molecular oxygen to generate singlet oxygen to treat various diseases. Photosensitizer is a key component and its optical properties and singlet oxygen quantum yield determine the effectiveness of its photodynamic reaction. This study evaluated the singlet oxygen production of a novel water solubility chlorin photosensitizer - namely YLG-I, which was developed in China. The absorption spectra and singlet oxygen luminescence different solvents were evaluated. It was estimated that the singlet oxygen quantum yield of the new photosensitizer YLG-I was at the same level of the potent chlorin sensitizer mTHPC. Preliminary evaluation suggested that YLG-I was a promising photosensitizer for PDT. This presentation will report the detection of singlet oxygen luminescence of the newly developed PDT sensitizer.

Citation Download Citation

Jian Zou, Jie Jiang, Zhen Han, Lisheng Lin, Yongzhen Li, and Zheng Huang "Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108203C (23 October 2018); https://doi.org/10.1117/12.2502481

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available