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23 October 2018 Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer
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Abstract
Photodynamic therapy (PDT) utilizes the combined action of photosensitizer, light and molecular oxygen to generate singlet oxygen to treat various diseases. Photosensitizer is a key component and its optical properties and singlet oxygen quantum yield determine the effectiveness of its photodynamic reaction. This study evaluated the singlet oxygen production of a novel water solubility chlorin photosensitizer - namely YLG-I, which was developed in China. The absorption spectra and singlet oxygen luminescence different solvents were evaluated. It was estimated that the singlet oxygen quantum yield of the new photosensitizer YLG-I was at the same level of the potent chlorin sensitizer mTHPC. Preliminary evaluation suggested that YLG-I was a promising photosensitizer for PDT. This presentation will report the detection of singlet oxygen luminescence of the newly developed PDT sensitizer.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jian Zou, Jie Jiang, Zhen Han, Lisheng Lin, Yongzhen Li, and Zheng Huang "Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108203C (23 October 2018); https://doi.org/10.1117/12.2502481
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