Evaluation of free-radical scavenging and antioxidant activities of polydatin nanoethosomes

Jia-zhen Du; Jia-Min Gao; Fan Shi; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang

doi:10.1117/12.2500148

25 October 2018 Evaluation of free-radical scavenging and antioxidant activities of polydatin nanoethosomes

Jia-zhen Du, Jia-Min Gao, Fan Shi, Tong-sheng Chen, Yi-fei Wang, Zhi-ping Wang

Proceedings Volume 10823, Nanophotonics and Micro/Nano Optics IV; 1082315 (2018) https://doi.org/10.1117/12.2500148
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Cellular damage induced by free-radicals like reactive oxygen species has been implicated in several diseases. The ROS radicals like alkoxy radical(RO-) and peroxy radical (ROO-) are similar to those that are physiologically active and thus might initiate a cascade of intracellular toxic events leading to DNA damage and cell death. Hence naturally anti-oxidant play a vital role in combating these conditions. In this study, polydatin nanoethosomes (Pol-NE) was prepared by high pressure homogenization technique. The effects of Pol-NE on free radical scavenging and antioxidant was investigated. The particle size and zeta potential of Pol-NE was 96.1±4.5 nm and -17.31±1.67 mV, respectively. By free radical scavenging and antioxidant assays, the IC₅₀ value of Pol-NE were 28.71, 9.83 μg/mL with DPPH, ABTS assay respectively, and 0.143 mg ferrous sulfate/1 mg Pol-NE with FRAP assay. These results indicated that the antioxidant properties of Pol-NE hold great potential used as an alternative to more toxic synthetic anti-oxidants as an additive in food, cosmetic and pharmaceutical preparations for the oxidative diseases treatment.

Citation Download Citation

Jia-zhen Du, Jia-Min Gao, Fan Shi, Tong-sheng Chen, Yi-fei Wang, and Zhi-ping Wang "Evaluation of free-radical scavenging and antioxidant activities of polydatin nanoethosomes", Proc. SPIE 10823, Nanophotonics and Micro/Nano Optics IV, 1082315 (25 October 2018); https://doi.org/10.1117/12.2500148

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available