Quantitative compressional OCE: obviating pitfalls in using pre-calibrated compliant layers and some other practical obstacles

Alexandr A. Sovetsky; Alexander L. Matveyev; Lev A. Matveev; Ekaterina V. Gubarkova; Marina A. Sirotkina; Grigory V. Gelikonov; Elena V. Zagaynova; Natalia D. Gladkova; Alex Vitkin; Vladimir Yu. Zaitsev

doi:10.1117/12.2280209

10 August 2018 Quantitative compressional OCE: obviating pitfalls in using pre-calibrated compliant layers and some other practical obstacles

Alexandr A. Sovetsky, Alexander L. Matveyev, Lev A. Matveev, Ekaterina V. Gubarkova, Marina A. Sirotkina, Grigory V. Gelikonov, Elena V. Zagaynova, Natalia D. Gladkova, Alex Vitkin, Vladimir Yu. Zaitsev

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Proceedings Volume 10831, Seventh International Conference on Lasers in Medicine; 108310K (2018) https://doi.org/10.1117/12.2280209
Event: Seventh International Conference on Lasers in Medicine, 2017, Timisoara, Romania

Abstract

In this report we discuss some practical obstacles/pitfalls arising in realization of quantitative compressional OCE, as well as discuss possible ways of their resolution. More specifically we consider (i) complications in quantification of the Young modulus of tissues related to influence of partial adhesion between the OCT probe and pre-calibrated reference layers - "compliant sensors", (ii) distorting influence of surface curvature/corrugation on strain distribution in the tissue bulk, (iii) ways of enhancement of effective SNR in OCT-based strain mapping without periodic averaging, and (iv) potentially significant influence of nonlinearity of the elastic response of biological tissues on quantification of their stiffness.

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Alexandr A. Sovetsky, Alexander L. Matveyev, Lev A. Matveev, Ekaterina V. Gubarkova, Marina A. Sirotkina, Grigory V. Gelikonov, Elena V. Zagaynova, Natalia D. Gladkova, Alex Vitkin, and Vladimir Yu. Zaitsev "Quantitative compressional OCE: obviating pitfalls in using pre-calibrated compliant layers and some other practical obstacles ", Proc. SPIE 10831, Seventh International Conference on Lasers in Medicine, 108310K (10 August 2018); https://doi.org/10.1117/12.2280209

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KEYWORDS

Tissues

Silicon

Natural surfaces

Optical coherence tomography

Elastography

Tumors

Glasses

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