Sinogram cleaning procedure for optical diffraction tomography

Wojciech Krauze; Małgorzata Kujawińska

doi:10.1117/12.2319580

7 September 2018 Sinogram cleaning procedure for optical diffraction tomography

Proceedings Volume 10834, Speckle 2018: VII International Conference on Speckle Metrology; 108341Q (2018) https://doi.org/10.1117/12.2319580
Event: SPECKLE 2018: VII International Conference on Speckle Metrology, 2018, Janów Podlaski, Poland

Abstract

Limited angle optical diffraction tomography is a technique that allows for non-destructive and quantitative analysis of biological samples directly from Petri dishes and microscope slides. Recently, a new reconstruction method, called Generalized Total Variation Iterative Constraint (GTVIC), was proposed. It is an iterative modular technique that calculates the reconstruction without the errors that are otherwise present due to limited angular range of projections. Unlike other similar techniques, GTVIC is dedicated to biological structures that have non-piecewise constant refractive index distribution. However, GTVIC is sensitive to local deviations of the immersion refractive index from its nominal value. Such deviations are present due to e.g. dust or cellular debris in the measurement volume. Therefore, we propose a method for preprocessing of a sinogram that numerically removes unwanted objects from the measurement volume without affecting the investigated object and its diffraction pattern. The described method is found useful in any tomographic algorithm that utilizes support constraint in the reconstruction process.

Citation Download Citation

Wojciech Krauze and Małgorzata Kujawińska "Sinogram cleaning procedure for optical diffraction tomography", Proc. SPIE 10834, Speckle 2018: VII International Conference on Speckle Metrology, 108341Q (7 September 2018); https://doi.org/10.1117/12.2319580

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