Instrument for measurement of singlet oxygen for studies of skin under UVA irradiation

S. J. Davis; D. I. Rosen; J. England; M. F. Hinds; R. K. Sivamani; W. Burney

doi:10.1117/12.2510039

26 February 2019 Instrument for measurement of singlet oxygen for studies of skin under UVA irradiation

S. J. Davis, D. I. Rosen, J. England, M. F. Hinds, R. K. Sivamani, W. Burney

Proceedings Volume 10851, Photonics in Dermatology and Plastic Surgery 2019; 108510J (2019) https://doi.org/10.1117/12.2510039
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this paper we will describe a non-intrusive, optically-based instrument that can quantitatively measure singlet molecular oxygen, a constituent of reactive oxygen species (ROS) produced by irradiation of human skin by the longer wavelength UV radiation known as UVA. UVA is causally associated with DNA damage and subsequent development of melanoma. We will present data from healthy human subjects that show formation of singlet molecular oxygen and concomitant production of thymine dimers, indicative of DNA damage. We will also discuss how this instrument may be a valuable tool for the development of more effective sunblock formulations for UVA.

Citation Download Citation

S. J. Davis, D. I. Rosen, J. England, M. F. Hinds, R. K. Sivamani, and W. Burney "Instrument for measurement of singlet oxygen for studies of skin under UVA irradiation", Proc. SPIE 10851, Photonics in Dermatology and Plastic Surgery 2019, 108510J (26 February 2019); https://doi.org/10.1117/12.2510039

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KEYWORDS

Oxygen

Skin

Luminescence

In vivo imaging

Picosecond phenomena

Tissue optics

Ultraviolet radiation

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