High speed in vivo endoscopic photoacoustic and ultrasound dual-modality imaging (Conference Presentation)

Yan Li; Zhikai Zhou; Joseph Jing; Emon Heidari; Youmin He; Jiang Zhu; Teng Ma; Mingyue Yu; Qifa Zhou; Zhongping Chen

doi:10.1117/12.2505747

4 March 2019 High speed in vivo endoscopic photoacoustic and ultrasound dual-modality imaging (Conference Presentation)

Yan Li, Zhikai Zhou, Joseph Jing, Emon Heidari, Youmin He, Jiang Zhu, Teng Ma, Mingyue Yu, Qifa Zhou, Zhongping Chen

Proceedings Volume 10854, Endoscopic Microscopy XIV; 108540D (2019) https://doi.org/10.1117/12.2505747
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Colorectal cancer, the third most common type of cancer globally, has ~1.4 million new cases and 694,000 deaths annually. Endoscopic photoacoustic (PA) imaging is a non-invasive imaging modality that provides structural, functional and molecular information while maintaining a deep depth. Several groups have reported different designs of endoscopic PA imaging systems that represent a significant step forward for the characterization of gastrointestinal (GI) cancer. However, these imaging systems are still not adequate for in-vivo clinical translation due to insufficient field-of-view, large probe diameters, and slow imaging speed. Endoscopic dual-modality photoacoustic and ultrasound imaging has the potential for early detection of cancer in the gastrointestinal tract. Currently, slow imaging speed is one of the limitations for clinical translation. In this study, we demonstrate an integrated endoscopic PA and US imaging system. Utilizing a high repetition rate pulsed laser, optimized rotary joint as well as proximal scanning method, this integrated imaging system is able to obtain morphological tissue information and vasculature of the GI tract simultaneously at a high imaging speed up to 50 frames/s (the fastest speed reported to date). We conducted in-vivo animal studies to demonstrate the performance of our imaging system for evaluating the GI tract. The results obtained from the in-vivo rat experiment showed that the typical layered architecture and vasculature can be identified by this integrated system with a high imaging speed.

Conference Presentation

Citation Download Citation

Yan Li, Zhikai Zhou, Joseph Jing, Emon Heidari, Youmin He, Jiang Zhu, Teng Ma, Mingyue Yu, Qifa Zhou, and Zhongping Chen "High speed in vivo endoscopic photoacoustic and ultrasound dual-modality imaging (Conference Presentation)", Proc. SPIE 10854, Endoscopic Microscopy XIV, 108540D (4 March 2019); https://doi.org/10.1117/12.2505747

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Imaging systems

Endoscopy

In vivo imaging

Photoacoustic spectroscopy

Ultrasonography

Cancer

Colorectal cancer

Show All Keywords

Keywords/Phrases

Search In:

Publication Years